Background: Various studies have shown lipoproteins to be involved in the pathogenesis of atherosclerosis. Lecithin cholesterol acyltransferase (LCAT) plays significant role in the lipoprotein metabolism but its association with atherosclerosis is still to be known.
Aim: To evaluate the level of serum LCAT and study their association with angiographically proven atherosclerosis.
Materials and methods: Study population consisted of angiographically proven 50 cases with atherosclerosis and 50 controls without atherosclerosis. Serum lipid profile was measured on SYNCHRON CX-9 using standard kits. Serum LCAT level was measured by ELISA method. Results: No statistically significant difference found in LCAT level and lipid profile of cases and controls.
Conclusion: We conclude that LCAT is not associated independently with angiographically proven atherosclerosis but rather its role is dependent on the availability of other mediators of reverse cholesterol transport pathway like HDL and CETP.
