Elevated YKL – 40 levels are seen in patients with type 2 diabetes.Interleukin-6 is one of the most studied inflammatory markers in periodontal disease. Aim was to estimate and compare GCF levels of YKL-40 and Interleukin-6 in healthy, chronic periodontitis and type 2 diabetes mellitus patients with chronic periodontitis.82 patients were enrolled into the study and divided into three experimental groups healthy group, chronic periodontitis group and chronic periodontitis with type 2 diabetes mellitus group. Gingivalcrevicular fluid samples were collected and YKL-40 and Interleukin-6 were analysed by enzyme linked immunosorbent assay. The total amount of YKL-40 and IL-6 in GCF were higher in patients with periodontal tissue breakdown. Within the limits of this study it can be concluded that YKL-40 in GCF may reflect the inflammation of periodontitis and can be a useful marker for inflammation in periodontal diseases and type 2 diabetes mellitus
