Infertility is a major issue which affects population worldwide. We aimed to evaluate the long term effect of one of the active component of sesamum indicum, sesamol on spermatogenic activity in male wistar albino rats. The animals were divided into experimental group and control group. (n=6 each) The experimental groups were orally administered with sesamol (25mg/kg bwt) for 6 weeks. The control group received the same volume of 0.9% saline for the same duration. Differences between the groups were analyzed by unpaired t test. Oral administration of sesamol showed a significant (P < 0.01) increase in the weight of the reproductive organs. Further, significant increase (P < 0.001) in total sperm count was seen in treated group of rats when compared to controls.
