The expression of mammaglobin gene is predicted to be highly specific in breast cancer. The role of mammaglobin expression as a prognostic and therapeutic tool in breast cancer is widely accepted. The aim of this study was to investigate immunohistochemical expression of mammaglobin, and to determine the correlations with clinicopathological parameters. In the present study, immunohistochemical analysis of two hundred breast carcinoma patients was performed. The immunohistochemical reaction was scored based on the percentage of positive tumor cells. The positive expression rate of mammaglobin biomarker was observed in 69% of breast cancer patients. Tumor grade was found to be significantly associated with the Expression of mammaglobin (p=0.0017). Maximum patients (45%) were observed with tumor size 2-4.9 cm. No statistically significant association was observed among mammaglobin expression, tumor size, lymph node status and histological types. In conclusion, we suggested mammaglobin gene as excellent candidate for a novel and clinically useful breast tumor marker and help in management of breast cancer patients.
