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“Transposition” is defined as an interchange in the position of two teeth within the same quadrant of the dental arch. Canines are the most frequently transposed teeth (1) in dental arch owing to the fact that they have slower development, longer eruption pathway and last anterior teeth to erupt in the mouth hence, have insufficient amount of space, which often results in ectopic eruption. This case report illustrates the treatment of a 14 year old female patient with transposed maxillary canines and premolars. The treatment progressed through mini-screw supported anchorage to orthodontically move 13 to the normal anatomic position and to maintain 23 in the transposed position between the 1st and 2nd premolar in the 2nd quadrant. The treatment duration was 24 months at the end of which debonding was carried out and stable occlusion was established. The case report also presents an one-year follow up of the occlusion. The treatment gave an acceptable esthetic result, occlusion, patient comfort, patient and parent satisfaction, treatment duration, periodontal support. The patient and her parents were extremely satisfied with the results.