Minimally Invasive Periodontal Surgery (MIPS) is a surgical technique using small incisions indicated for performing regenerative therapy in periodontal defects. It can be performed using magnification from surgical microscopes, surgical telescopes, or endoscopic visualization. MIPS seals the healing wound from the contaminated oral environment by ensuring primary closure. Preserving soft tissues and maintaining minimal gingival recession, minimal hypersensitivity claim to be essential requisites to meet the demands of the patient and the clinician in the esthetic zone. Minimally invasive methods for periodontal treatment yield long-term reductions of probing depths and enhanced clinical attachment levels. The exclusive property of MIPS is that it reduces the chair time required to perform the procedure and results in limited morbidity to the patient during the surgical procedure, as well as in the postoperative period. However, it cannot be applied in all cases. A stepwise decisional algorithm should support clinicians in choosing the proper approach.