Vitamin D, is a steroid that plays endocrine, paracrine and autocrine functions; obtained by cutaneous photo exposure to ultra violet and diet, or supplements; its greatest importance form is Vitamin D3.Vitamin D deficiency is linked to many diseases such as Vitiligo disease and almost of autoimmune disease as diabetes (type 1 or latent autoimmune diabetics). In this Review, we discuss the important role of Vitamin D with Vitiligo disease. Vitamin D and its receptor found to have been assured the immunoregulation through down-regulating T-helper1 immune responses with proinflammatory cytokine, Inhibiting the B-cells differentiation, T-lymphocytes proliferation and immunoglobulin secretion;. However, Vitamin D has photo-protective and antioxidant effects by the blockage of DNA (Deoxyribonucleic acid) damage factor of in mitochondria. Moreover its induced the proliferation of epidermis and increased the level of dihydroxyphenylalanine-positive melanocytes. The conclusion can be drawn that Vitamin D has the propensity ensure the repigmentation to restoring skin color in a patient with vitiligo disease.
