The objective of the research work was to evaluate and compare the stability and shelf life of in situ implant systems of anti-inflammatory drug, Deflazacort. In situ forming implants had gained wide attention as a formulation approach for those drugs intended to be used in chronic conditions where drug usage extended for weeks or months. Many limitations are reported to be associated with these delivery systems of which poor stability and short shelf life was major and need to be addressed. In this research work, in situ implant formations of Deflazacort was designed using combination of poloxamer 188 and poloxamer 407 as thermo responsive polymers in one approach while in the other PLGA copolymer was used. Evaluation of the formulations were done based on gelation temperature, gel melting temperature, gelling time, gel duration and % entrapment efficiency. Both formulations showed absence of any significant changes in formulation characteristics during stability study period, indicating high stability. Shelf life studies concluded that, in situ implant systems based on Poloxamer 188 and 407 exhibited a shelf life of1.86 years, while PLGA based formulations, had a shelf life of 2.083years.
