Plants contains bountiful of potentially useful constituents for the development of novel therapeutic agent, hence in recent years drug development in phytomedicine has gained considerable interest. With the emergence of MDR pathogens and insufficient treatment strategy with antibiotic, investigators turned eye in search of alternative potential approach for treatment. Phytochemicals is a unified and unique complex of natural components having therapeutic efficacy. Biological activity of phytochemical is associated with its chemistry. It elaborates the development of natural products, combining it with modern antibiotics to confer its action against MDR pathogens. Present review has been aimed to summarize past practices and latest issues of medicinal plants and its phytoconstituents in medical microbiology against MDR pathogens. It also deals with vast ancient knowledge and its diverse applications, and rejuvenation of therapy with synergistic action of antibiotics and phytochemicals, and its mechanism of action.
