O-alkyl/O-aryl trithiophosphates of Vanadium (III) of general formula V[SSH(S)POR]3 where ( R= Me, Et, Pri , Bui , Ph, CH3Ph ) have been synthesized by the reaction of Vanadium trichloride and Oalkyl/O-aryl trithiophosphoric acid in 1:3 molar ratio, respectively and refluxed in methanol. The newly synthesized derivatives are dark green sticky solids which convert into needle liked crystals, insoluble in common organic solvent but soluble in co-ordinating solvents like DMSO, DMF etc. These derivatives have been characterized by elemental analysis (C,H,S), molecular weight measurement and spectral studies such as IR and NMR(1 H, 13C, 31P). On the basis of above chemical parameters and spectral studies, bidentate behaviour of trithiophosphate ligand and octahedral geometry have been proposed for these monomeric derivatives. The newly synthesized derivatives show effectiveness for antibacterial activities against gram positive and gram negative bacteria. Comparative study of antibacterial effect has also been made with standard drugs. Paper disc method was used for antibacterial activities
