Concept of Ama is very unique in Ayurveda non other science mentions Ama as a cause of disease it is produced by flawed digestion in gastrointestinal tract or in the tissues by defective metabolic processes. Ama thus produced is said to circulate and block the vessel of the joints and get deposited there causing the disease Amavata. Amavata is a common disease encountered by physicians in dayto-day life.. Due to progressive, chronic nature of disease it affects the quality of life of patients and decreases their productivity at work. In the Present article the causative factors, prodromal symptoms, types, disease manifestation, progression of disease, Investigations treatment protocols adopted and formulations as per classical reference in Ayurveda in the disease “Amavata” with Special Reference to Rheumatoid Arthritis” is reviewed in integration with modern medical facts. This article also compiles research works adopted in Amavata with its results.