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Nursing professionals are exposed to various occupational risk situations during the performance of their activities. Such risks originate from unhealthy activities, triggering the onset of diseases and accidents at work. The research aimed to evaluate the level of knowledge of nursing professionals on the occupational hazards in an intensive care unit, and biosecurity measures. The work presented here, is based on a descriptive exploratory qualitative study, theoretical research associate, held from the understanding of occupational hazards in the hospital environment. As a result, it was found that the potential occupational risks that originate from unhealthy activities taking these professionals an exhibition exacerbated the dangers present in the work environment, because adverse effects to the health of this worker, setting off from the emergence of disease to accidents at work. It is concluded that the concern to meet the demands of maintaining occupational health appears as an integrator of the formation of the nurse. Finally, we highlight the importance of continuing education deemphasizing the theme of occupational hazards with illustrative demonstrations, as well as intensify studies in this area, both geared to students and professionals, reducing possible accidents of job.