The present study aimed to investigate the chemopreventive and antioxidant efficacy of fisetin on 7,12-dimethylbenz(a)anthracene(DMBA) induced hamster buccal pouch carcinogenesis in golden Syrian hamsters. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. We observed 100% tumour formation as well as, the status of lipid peroxidation, antioxidants and phase II detoxification enzymes were siginificantly altered during DMBA induced oral carcinogenesis. Oral administration of fisetin at a dose of (10mg/kgb.wt) to DMBA treated animals significantly prevented the tumour formation in the hamster buccal pouch and regained the status of lipid peroxidation, antioxidant. The above results suggest that the fisetin has potent chemopreventive and anti lipidperoxidative effect during DMBA induced oral carcinogenesis.
