Bones are dynamic, viable, highly organised living tissue and is the main constituent of musculoskeletal system. Though the main function of bones is to protect the internal structures and to provide support to various soft tissues, additionally they also provide haematopoiesis in bone marrow. Bone constantly responds to the varying functional demands through continuous adaptation. This process of adaptation is known as ‘remodeling’. Bone modeling is a result of a balance between bone formation by osteoblasts and bone resorption by osteoclasts. It is a continuous process and at any given time approximately 5-25% of bone surface undergoes remodeling. As normal physiological bone remodeling is imperative for the maintenance of bone strength and integrity, any imbalance, will either lead to increase or decrease in bone mass. Significant understanding of the interplay between different factors governing bone remodelling will potentiate better treatment options for pathologies involving the hard tissue.
