The present study deals with determination of floating characteristics of Sucralfate and Metoprolol Succinate by radiographic imaging techniques as in vivo evaluation method by rabbit as model.The best formulation of Bi layered floating tablet of Sucralfate and Metoprolol succinate is taken. The floating characteristics of Sucralfate and Metoprolol Succinate is determined by In-vivo X-Rays Studies (Radiographic imaging technique) implemented after the ingestion of the tablet. The rabbits were exposed to X-Ray photography and floating efficacy of floating tablet at different time intervals in rabbit’s stomach are show in the stomach region at 40mA, 45KV, and 5mAs at different time intervals for 0, 1, 2, 4, 6 hours. The distance between the source of X- ray and rabbit abdomen was kept constant (80 cm) for all images After 2 h and 4 h administration of floating tablet showed that floating tablet was still found to be buoyant on gastric content, respectively. at 6h after administration of floating tablet showed that floating tablet at lower gastric region displayed still buoyant position..The formulation showed better floating capacity confirming potential of floatingdrug delivery system for prolonging gastric residence and enhancing local effect.
