Staphylococcus aureus infections in human as this bacterium is resistant to methicillin. Natural products from higher plants may give a new source of antimicrobial agents. In this study, Cannabis sativa and Thuja orientalis have been chosen and findings of their individual contents’ inhibitory role on MRSA is studied and compared. The 3 MRSA bacterial cultures were isolated, as MG1, IR0 and IR2, first two were found to be resistant to Methicillin antibiotics while, IR0 showing the highest zone of inhibition with C. sativa and T. orientalis plant extracts. Respectively, 9-THC, CBDA, CBD and CBN components were separated from the Cannabis leaves and LEA1 , LEA2 , LEA3 and LEA4 various unknown components were separated from Thuja leaves using thin layer chromatography. However, a higher zone of inhibition was observed in 9-THC component of Cannabis against MG1 and LEA4 component of Thuja against IR2 isolates. 9-THC and CBD components of Cannabis proved best. These natural components can be formulated for topical use to cure infections caused by MRSA because of their promising anti-MRSA activity.
