Osteoarthritis (OA) is a disease of cartilage degradation, which results pain in major joints, especially in knee joint. Globally OA ranks eighth in all diseases and covers around 15% proportions among all musculoskeletal problems. Clinical symptoms and radio-diagnosis are the basis of diagnosis used for OAcharacterization. India has higher proliferative rate of OA among world and expected to be at top rank in chronic diseases till 2025. There is very limited literature present on OA epidemiology. This paper tried to compile the regional prevalence of OA among India by using sexual as well as geographical parameters. Andhra Pradesh has highest prevalence among India. In Andhra Pradesh and Bihar, exceptionally males are highly affected than females.