Introduction: Bladder cancer represents 4.9% of total neoplastic deaths in males and 1.8% in females (3). And the 3rd tumor by prevalence in Italy In the Italian Association of Tumor Registries (AIRT), every year, 70.7 cases of bladder cancer per 100,000 men and 16.3 per 100,000 women were diagnosed on average. In Eastern Sicily On 1646 (75-80) cases in 84% the disease affects the male and the remaining 16% the female also has a net chance of casualty between urbanization and industrialization with the increase in the incidence of bladder neoplasms. Material and Methods: In the Department of Specialist Surgery II of the Clinical Hospital of Catania from January 2010 to December 2016, there were n 152 patients with bladder n 127 males in 25 females and mean age 65. of these n 90 (60%) affected From ca infiltrating in 60 (40%) with non-infiltrating ca). Screening carried out with non-invasive investigations due to hematuria and urinary cytology included the following examinations: Ultrasonography, urinary cytology Uretrocistoscopy Fluorescence cystoscopy URO-TC RMN PET molecular urinary test Results: Surgical treatment in 29 cases (48.9%) With non-infiltrating bladder tumor was to undergo TUR-B. The patients. In 51% of cases there was a tumor of less than 1 cm, while in the remaining 49% the tumor was more than 1 cm with the presence of an associated cis in 10% of the cases (n 3 paz). The objectives of -TUR-B were: complete eradication of the tumor; The correct staging; The optimization of the therapeutic and follow up program. The presence of residual tumor at TUR involved n 9 cases (15%) was a prognostic negative prognosis of recurrence and progression (12.13) of the disease present in highrisk tumor (high grade T1) Discussion: in tumor Non-infiltrating bladder is based on the definition of 6 predictive factors that can be deduced at TUR: 1-Number of tumor , 2-Size of the tumor 1- Previous recurrence rate2 -Stadio of the tumor (T) 3-Presence of concomitant CIS4 -Grade of tumor (G) The identified parameter codes encode a risk score that is predictive of reduced survival: -Base Risk: single lesion, Ta, G1, diameter 3 cm-High risk: multifocality, high relapse rate, T1 stage, G3 grade, CIS, these parameters were adopted in the study and treatment of patients with satisfactory clinical picture Ermade to point to the treatment that has resulted in T2 survival beyond 120 months). Another important factor in TUR-B remains the decline in the risk of residual tumor after TUR for Ta-T1 tumors, with accurate staging. Conclusion: Radical cystectomy confirms the choice of treatment for bladder infiltrating cancer that determines the best results in all age groups, feasible and welltolerated by the elderly population with morbidity and mortality rates that can be overlapped by the global population. Neo-Adjuvant chemotherapy has many advantages: 1 It permits an in vivo drug sensitivity test 2 It is better tolerated 3The response can have a prognostic value 4 It can make a tumor initially inoperable.
