Objectives: The present research was framed to investigate the relationship between personality traits (Neuroticism and Psychoticism tendencies) and perceived stress among medical college students. Methods: The sample included a total of 60 students. Two measures were used i.e. Hans Eysenck personality questionnaire (EPQ-R) and Sheldon Cohen perceived stress scale. Means and SDs were computed and Pearson product movement correlation was applied to check the relationship between personality traits and perceived stress among medical college students. Result: The correlation score between neurotic personality trait and perceived stress is 0.45 and it is significant at 0.01 level. It indicates that higher the level of neuroticism greater the perceived stress. The correlation score between psychoticism personality trait and perceived stress is 0.43and it is significant at 0.01 level. These indicate the correlation between psychoticism personality trait and perceived stress is negative. Conclusion: The result revealed that relationship was found in neurotic and psychotic tendencies with perceived stress. On the basis of obtained result researchers can conclude that personality (neurotic and psychotic tendencies) leads to significant alleviation of perceived stress.