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Plant growth promoting rhizobia (PGPR) belongs to the various families of Phyllobacteriaceae, Rhizobiaceae and Bradyrhizobiaceae. The nutrition and inhabitation of PGPR is sustained by the niche known as Rhizosphere. PGPRs inculcate numerous benefits specifically for mechanisms including defence mechanism against pests and diseases through activation of defence pathways and development of wide range spectrum resistance to overcome extreme abiotic or combinatorial stress conditions such as over dosage of pesticides, fertilizers, salinity, drought, temperature, heavy metal contamination and pH on a variety of commercially important agricultural crops. PGPRs microbes offer enhanced plant growth and yield with nutrient enrichment of soil using their remarkable property of nitrogen fixation, siderophore production, phosphate solubilisation influencing soil fertility and cellulase, protease, lipase enzyme production to enhance plant defence mechanism. Our review summarizes the importance of efficacy of screening, selection and commercialization to agricultural production sustainability.