Wound healing is a complex biological process which helps in repair or regeneration of damaged tissue. Platelet rich fibrin was introduced in 1990’s. Platelet rich fibrin is a second-generation platelet concentrate widely used to accelerate soft and hard tissue healing and is a strictly autologous fibrin matrix containing a large quantity of platelet and leukocyte cytokines. Ross et al. were amongst the pioneers who first described growth factor from platelets. Choukroun’s Platelet rich fibrin has been the latest development among the platelet concentrates. Growth Factors presentin platelet rich fibrin, Leucocyte activation platelet rich fibrin dwells among a new generation of platelet concentrate that jump-starts the healing process to maximize predictability. The major difference between platelet rich fibrin from platelet poor plasma which contains platelets, leukocytes, macrophages, neutrophils, lack of anticoagulant and presence of natural growth factors which enhance factor and more potent wound healing and regeneration. Newer advancement of platelet rich fibrin is advanced platelet rich fibrin which contains porous structure, more number of leukocytes leads to significantly enhance vascularisation. Apart from medicine, platelet rich fibrin is the most promising regenerative material in dentistry. This article we discuss about various uses of platelet rich fibrin in the field of dentistry
