Context: Various factors contribute to Congenital anomalies in Newborn. The quality of care in tertiary hospitals has improved overtime yet deaths occur due to congenital anomalies which are pictured unavoidable. This needs special focus to control the Infant mortality rate. Aim: To rule out the prevalence of congenital anomaly in a tertiary care hospital, type, factors related and its outcome Setting and Design: This is a hospital based retrospective study conducted in a tertiary care hospital. Method and Material: Three year Hospital data on neonates (2012-2014), born or admitted with congenital anomaly in a tertiary care hospital in Coastal Karnataka was collected manually. Quantitative analysis of data was done using SPSS version 16.0 to rule out the prevalence, type and factors related and outcome of congenital anomaly Statistical analysis used: The data collected was analysed using SPSS version 16. The result was given in terms of frequencies and percentages. Association was found between variables to rule out its significance using chi-square. Results: Total of 33 neonates with congenital anomalies were identified. Majority anomalies were related to digestive system and cardiovascular system. Mean age of mothers being 29.5yrs (±5.5years). Majority of the neonates with congenital anomaly were females. There was a positive association between Preterm Status and IUGR of the neonate (P value=0.03). About half of the mothers had complications like Pre-eclampsia, eclampsia, Gestational Hypertension, Oligohydramnios and Polyhydramnios. Half of these anomalies were undetected during the antenatal scan and 33% of these newborns died due to complications. Conclusions: Congenital anomalies and factors related has to be addressed to individuals to reduce disability and death related to congenital anomalies. Health care institutions have to be well equipped for emergencies to reduce death in newborns
