Back Ground: Transmission of infectious diseases such as HIV, hepatitis, syphilis and others through donated blood needs a serious monitoring. Provision of safe blood transfusion is warranted in all types of medical and surgical therapy. PRM Medical College and hospital provides health services to people of north Odisha and neighbouring districts of Jharkhand and West Bengal. Odisha blood bank, Baripadafulfills the blood need of the hospitals, nursing homes and nearby other health institutions. Objective: This study was under taken to know the magnitude of seropositivity amongst blood donors and plan for donor safety. Materials and methods: A prospective observational study was conducted for a duration of 8 years in the Odisha blood bank from 1st January 2010 to 31st December 2017.All the donor blood samples were screened for HIV, HBsAg, anti- HCV by ELISA method . Syphilis was screened by RPR kit and malaria by ICT card method. Donors already known seropositive for these infections and hemoglobin less than 12.5 g% were excluded. Results: Among the total 53,786 donors 22,217 (41.31%) were replacement donors while 31,569(58.69%) were voluntary donors. Male donors (48,798) comprised 99.08% and the remaining were female donors 4988(0.92%).Total seropositivity found were 1.463% including0.128% for HIV, 0.394% for HBsAg, 0.120% for HCV, 0.113% for Malaria and 0.706% for Syphilis. Conclusion: Seropositivity for TTIs in healthy donors comprises 1.463%; thus, a potential for transfusion through blood transfusion. So, a strict donor screening with higher generation ELISA kit is warranted to prevent transmission of various infections through blood products.
