This prospective study aims to determine the anatomical and visual results of Therapeutic Penetrating Keratoplasty and its role in the management of corneal diseases. Penetrating keratoplasty is the final therapeutic option in the management of refractory corneal disease after conventional medical therapy fails to prevent corneal perforation.(1) Out of the 42 cases that underwent Penetrating keratoplasty in Karwar Institute of Medical Sciences and Hospital, Karwar from February 2018 to January 2019, 62% of cases were males and 38% were females. Male to Female ratio was 1.63:1. 95% of the cases were anatomically successful while 48% cases showed visual improvement. Post-operatively vision improved to FC 1mt - 6/60 in 20 (48%), while 18 (42%) patients remained between hand movements and counting fingers close to face. In 4 (10%) patients visual acuity was only perception of light (PL). Careful planning and selection of the patients and surgical techniques also influences the final outcome of the procedure.
