The present study was designed to investigate the preventive potential of vanillic acid (VA) on isoproterenol (ISO)-induced oxidative stress and heart mitochondrial damage in rats. Male albino Wistar rats were pretreated with VA (10mg/kg, body weight) once daily for 10 days. After the pretreatment antioxidant, and oxidative stress parameters in serum and heart tissues were measured. ISO treated rats showed the activity of myoglobin was increased significantly (p < 0.05) in the serum of ISO rats. Furthermore, the levels of lipids such as total cholesterol, triglycerides and free fatty acids in the mitochondrial fraction of the heart. TEM findings also correlated with these biochemical parameters. These findings revealed the preventive effects of VA against ISO-induced oxidative stress and cardio toxicity in rats. These observed effects are mediated via antioxidant power and free radical scavenging activity of VA.
