Background: Although little information is available regarding the real prevalence of PMDs in the general population, a commonly accepted prevalence of 13.7% has been reported in Indian population. 40-69 years is the average age of patients with PMDs, which is 5 years before occurrence of oral cancer. Thus there are lot of such cases that requires a periodontal regenerative therapy and this study is carried out to assess the usefulness of regenerative procedures in OPMD cases. Materials and Methods: Sixty patients were divided into four groups, i.e., 15 samples in Group 1 (Leukoplakia);15 samples in Group 2 (Oral Lichen Planus), 15 samples in Group 3 (Oral Submucous Fibrosis) and 15 samples in Group 4 (Control) with random gender distribution. PRF was prepared from blood samples of all patients and were subjected to cell block cytology method of histological analysis and slides were prepared to histologically assess the changes in (i) Weight of PRF (ii) fibrin network patterns in terms of density and (iii) entrapment of platelets and white blood cells (WBCs) within fibrin meshwork. Results: In the present study quantitative and qualitative assessment of the PRF clot comprising its fibrin density and pattern of localization of WBCs and platelets in the OPMDs and normal counterpart inculcated to have a highly significant correlation(p value<0.05). Conclusion: From the current study it can be concluded that Oral potentially malignant disorders can be considered as one of the influencing factors on quantity of PRF as well as on the fibrin network pattern. Thus treatment plan involving PRF in such patients should be modified. INTRODUCTION The clinical concept of malignant transformation in oral mucosa has been proposed for more than 100years.The World Health Organization (WHO) defined the term "potentially malignant disorders" as the risk of malignancy being present in a lesion or condition either during the time of initial diagnosis or at a future date. Even though little knowledge is available regarding the real occurrence of PMDs in the general population, a commonly accepted prevalence of13.7% has been reported in Indian population. Average age of patients with PMDs is 40-69 years, which is 5 years before occurrence of oral cancer. Unfortunately, in recent years 5% of PMDs has been observed in personsunder 30. Premalignant disorders are usually found on the buccal mucosa, followed by gingivae, tongue and floor of the mouth.[1] The following disorders are regarded as being potentially malignant: 1) Leukoplakia/Erythroplakia, 2)Oralsubmucous fibrosis, 3) Palatal lesions in reverse smokers, and, although still somewhat questionable 4) Oral Lichen Planus, and 5) Discoid Lupus Erythematosus.[2] The prevalence of leukoplakia for all ages is approximately 4.02%, with an increasing prevalence in adults.
