Vaspin had been identified as a novel adipokine with high expression in adipose tissue of obese and type 2 diabetic subjects and with potentially insulin sensitizing properties. Aim: To assess the relationship between serum vaspin and the presence of macro vascular complications in type 2 diabetic cases. Our case control study was conducted onsixtytype 2 diabetic patients, twenty with coronary artery disease, twenty with cerebrovascular stroke and twenty diabetics without complications. Twenty healthy subjects were our control group. All participants were subjected to medical history, thorough clinical examination and lab measuring of serum Vaspin, FBG, 2hPG, HbA1c, lipid profile and microalbuminuria and had echocardiography Carotid duplex and CT brain. Serum vaspin was lower in diabetic patients with macro vascular complications than in healthy group and also significantly positively correlated with diabetes duration, lipid profile, indices of hyperglycemia and carotid intimal thickness. Vaspin might play a role in the development of diabetes and its macro vascular complications. So, it may be used in the future in the treatment strategies.
