Bioactive compounds were extracted from the leaves of Anthocephalus cadamba using standard method. Different compounds of the most active extract were identified by the gas chromotographymassspectrometry (GC-MS) analysis. All plant extracts showed significant larvicidal activity against A. aegypti mosquito larvae at 0.05 level of significance. Tinospora rumphii leaf extract is the most effective mosquito larvicide which is manifested by the highest percentage mortality on the larvae of 90% and 93% after 24 and 48 hours respectively; with an LC50 and LC90 values of 10 mg/mL and 46 mg/mL respectively after 48 hours of exposure. Citrus grandis bark and Tinospora rumphii stem extracts showed a significant difference on the increased of the mortality of mosquito larvae with increasing concentrations of the plant extracts at 0.05 level of significance. The high larvicidal activity of Tinospora rumphii leaf is supported by the abundance of phytochemicals which show synergestic effects in terms of larvicidal action to mosquito larvae. The larvicidal activities of the three plants differ according to the plant species and part used which is supported by the presence of several bioactive chemicals.
