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The reproduction and production of F1 N’Dama x Monthéliarde (F1Monthéliarde) and N’Dama x Holstein (F1Holstein) were analyzed on dairy station of Yamoussoukro in Côte d’Ivoire. Data collections were done from 2008 to 2016. The average first calving age of F1Holstein cows was 30.2±5.44 months for the average milk productions of 6.84±2.24 kg/day and 1933±781 kg/lactation (276±35.9 days). These F1Holstein were more productive than F1 Monthéliarde (average first calving age was 32.2±4.94 months for milk production of 5.76±2.06 kg/day and 1582±736 kg/lactation in 264±46.5 days).Also, our findings evidenced F1 Montbéliardes cows advantages in term of calving interval period (421±75.4 days) in comparison to F1 Holsteins (453±90.8 days). Otherwise, birth weight of F1Montbéliardes (females: 31± 1.73 kg;males: 31.7±2.89 kg) was significantly (p <0.05) superior to that theF1Holsteins(females: 22 kg; males: 23±1.73 kg). But, weight growth showed that the both hybrids had similar growth from 1 to 7 months before observing F1Holsteingrowth superiority.