To make an overview on multifunctional activities of Gastro Retaintive Drug delivery System.(GRDDS) This review deals with study upon recent literatures on needs, advantages and disadvantages , ,suitable and unsuitable drugs, pharmacokinetic aspect, mechanism, approaches, list of polymers and other ingredients used, in vitro and in vivo evaluation, literature survey, marketed products, patented formulations, applications, limitations, and future aspect of Floating Drug Delivery System. Incorporation of drugs in bilayer floating tablet remain in gastric region for several hours would significantly prolong the gastric residence time of drug and improve the bioavailability and reduce the drug waste and enhance the solubility of drugs that are less soluable in high environment. Bilayer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. It also may be extensively used to improve therapy with several important drugs.
