Collodion baby is phenotype resulting from different congenital disorders of keratinization characterized by the presence of a tight, translucent membrane that covers the entire skin at birth. It is a congenital disorder, occurring with an incidence of 1: 300,000 live birth and both gender are equally affected. Collodion baby is a descriptive term used for transient appearance of Neonates born with some form of congenital Ichthyosis . This membrane usually sheds around 10 to 14 days and reveals the underlying disease. It is associated with a mortality rate of approximately 11%. A rare variant of this phenotype (10% to 20%) clear spontaneously or later show only very mild ichthyosis, being referred to as self-healing collodion baby (SHCB).1,2,7,9.The condition resolved spontaneously within a few weeks and patient does not developed any other manifestation. Although no molecular analysis was performed, we contribute to the knowledge of the clinical features of this extremely uncommon and benign entity.
