Introduction: Blood transfusion is liquid organ transplantation. Many infectious diseases are likely to be transmitted by blood transfusion. Transfusion transmissible infectious agents are among the greatest threats to blood safety for recipient. According to NACO guidelines, all mandatory tests should be carried out and whole blood or components from any unit that tests positive should be discarded. Voluntary non-remunerated blood donation is the source of the safest blood supply to the transfusion service. In the Indian setup where voluntary donations are fewer and poorly structured, safety of blood could still compromised. Hence this study was undertaken to find out the to find and compare seroprevelence of HBsAg transfusion transmissible infection among voluntary and replacement blood donors and know demographic profile of donors with respect to age and sex. Materials And Methods: The study was done in Blood bank of S.N Medical College, Bagalkot from July 2012 to June 2013. The blood units were collected from voluntary and replacement donors. Sample collection: Two ml of blood sample was collected in labeled pilot tube at the time of collection of blood from donor tubing of blood bag the sample was further centrifuged at 3500 rpm for 5 minutes to obtain clear non hemolyzed serum. The samples were tested for HBV. Any donor meeting all criteria’s for eligibility of blood donation as mentioned in SOP, Blood Bank, S. N .Medical College, Bagalkot. Any donor not fulfilling the criteria was excluded. Screening Test for Hepatitis B was done by HEPACARD and confirmed by HEPAELISA. Results: A total number of 8187 donor’s blood units were screened. Replacement donors constituted 91.13% and remaining 8.7% were voluntary donors. The donor’s age ranged between 18-60 years with majority (73.96%) in the range of 18-35 years. 97.39% donors were males and female donors constituted only 2.61%. The seroprevelence of HBsAg was 2.90% in total donors. The seroprevelence in replacement donors (3.17%) was more than voluntary donors (0.14%). Out of the 238 HBsAg positive donors 237 were males. Conclusion: The risk of TTI cannot be eliminated completely even after mandatory testing of blood units because of risk associated with donations during window period. With advent of nucleic acid amplification techniques (NAT) western countries have decreased the risk of TTI to a major extent. Our study showed that the seroprevelence of HBV was more in replacement donors compared to voluntary donors. These results suggest that voluntary blood donor’s services are needed. There should be an establishment of nationally coordinated blood transfusion services
