Aim: To assess the proportion of Voluntary Blood Donors (VBD) and Replacement Blood Donors (RBD) and compare the prevalence of Transfusion Transmitted Diseases (TTD) in VBD and RBD and year wise trends of viral TTD’s in government hospital blood bank in central India. Methodology: A total of 46699 blood units were collected during four years period in blood donation camps and in blood bank. Donors were carefully selected by following strict donor’s selection criteria, taking history and after doing clinical evaluation. 2 ml of blood sample was collected in test tube at the time of bleeding and serum was screened for HBsAg, anti HCV, anti HIV 1 and 2 with commercially available third generation ELISA test kits. All reactive samples were retested before being labeled as seropositive. Comparative analysis of 4 years data was done for trend analysis & prevalence rates were compared among VBD and RBD by using Chi Square & Anova test. Results: VBD were 95.7% in our study. The overall prevalence of HIV, HBsAg and HCV was 0.15%, 0.7% and 0.04% respectively. Increasing & decreasing trend in all these TTDs was statistically significant. The differences in the prevalence of HIV, HBsAg & HCV between replacement and voluntary donors were statistically significant (p <0.05). Conclusion: Voluntary blood donors have significantly lower rates of prevalence of Transfusion Transmitted Infections (TTIs) as compared to replacement blood donors. Hence we should try to increase VBD.
