Background: Although blood transfusion is a life-saving modality, it is associated with certain infectious and non infectious risks, Transfusion Transmitted Infections (TTI) are quite hazardous among them. Transfusion-transmissible infectious agents such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) Syphilis and Malaria are among the greatest threats to blood safety for the recipient. To assess the magnitude of disease transmission and for its prevention and control, the study of its seroprevalence is important. Method: This prospective study was done in Blood donors in Blood Bank, Dept. of IHTM, SMS Medical college & Hospital Jaipur, which is the largest tertiary Health center in Rajasthan. Study aimed to determine the seroprevalence of HIV, HBV, HCV Syphilis and Malaria infections among blood donors in study centre. Study was done on 15173 Blood donors who met the standard criteria for donor fitness were screened for HIV, HBS, HCV, Syphilis and Malaria, from July 2017 to June 2018 (1 year).Results: Out of 15173 units collected, 237 (1.56%) units had seropositivity for HBsAg/, p24 Ag. & anti-HIV Ab/ anti-HCV Ab/ anti-Treponemal Ab, 1 unit revealed co infection infections with HIV-HBV. Seropositivity rates of HIV, HBsAg, HCV, Syphilis were 0.085%,1.25%,0.07%,0.15% respectively, no donor was found positive for Malaria among study population. Seroprevalence of TTI was more in replacement donors (1.15%) in comparison to voluntary donors (0.40%). Most common age group of blood donors (68.7%) was 18-30 years. Conclusion: Even with the implementation of effective preventive strategies, there is significant risk of transmission of infectious agents in India. Efforts to ensure an adequate and safe blood supply should include proper screening and striving for optimal use of blood and its products.
