Objective: To measure serum enzyme level of matrix metalloproteinase (MMP) in patients with Knee Osteoarthritis and to compare with ESR level, age, weight and height.
Methods: An MMP3 serum level was detected and measured by using Abcam ab100607 MMP3 Human ELISA Kit (USA). The serum samples aliquots were thawed on ice and were assayed at 1:2 dilutions. The study included 23 males and 49 females were recruited who are already effected with Knee Osteoarthritis. Results: MMP 3 were higher in Knee Osteoarthritis patients with different age group and sex.The difference between serum MMP 3 x2=30.529, p=0.082 and ESR level x2=22.944, p=0.347 were analyzed. The difference mean rank scores of serum MMP 3 69.38 and ESR 75.62 respectively. Since p-value =0.082 ≤0.05=α we accept the null hypothesis both MMP 3 and ESR levels in Knee Osteoarthritis patients were elevated.
Discussion: At the 0.05 level of significance, there exists enough evidence to conclude that there is a no difference in the median test scores (and, hence, the mean test scores) among the MMP 3 and ESR levels in Knee Osteoarthritis patients. The study is concludes that, there is considerable evidence that MMP3 is capable of mediating degradation leads to knee joint destruction.
