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The concept of visha (poison/toxin) in Ayurveda holds timeless significance in understanding and addressing toxic exposure. Ancient Ayurvedic texts provide profound insights into the sources, classification, and management of visha, many of which align with modern toxicological principles. Contemporary sources of toxins, including industrial pollutants, agrochemicals, and lifestyle-related exposures, pose significant health risks today. This review highlights the Ayurvedic classification of visha and its relevance in the modern context, serving as a guide for students, researchers, and healthcare practitioners. The discussion bridges classical Ayurvedic concepts with contemporary toxicology, offering a holistic understanding of toxic exposure and its mitigation.