Acute flaccid paralysis (AFP) is a clinical syndrome characterized by rapid onset of weakness, including (less frequently) weakness of the muscles of respiration and swallowing, progressing to maximum severity within several days to weeks.1,5The term "flaccid" indicates the absence of spasticity or other signs of disordered central nervous system motor tracts such as hyperreflexia, clonus, or extensor plantar responses.1,2 We studied 57 cases of acute flaccid paralysis admitted in a tertiary care hospital in west India during the period of 2016 to 2019. Clinical profile of all these patients were studied and various parameters such as age,sex,hospital course,recovery pattern,complications, etc. were recorded. Flaccid paralysis cases with onset of less than 4 weeks were included for study. All traumatic and spastic paralysis or patients who had flaccidity due to spinal shock were excluded. We found a number of causes for AFP (acute flaccid paralysis) and their characteristics were studied in detail. The results obtained by this study reinforced the fact that, in any patient presenting with AFP, Apart from GBS; other potentially reversible and treatable differentials must be kept in mind (such as hypokalemic paresis, Snake bite etc depending on history and other investigation).