A Study of Association Of Serum Lipid Profile With Stroke Severity On Admission. Background: Stroke is one of the leading cause of morbidity and mortality. WHO defined stroke as “rapidly developed clinical signs of focal disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than vascular origin.” OBJECTIVES: To find out the association between different parameters of lipid profile, i.e. serum total cholesterol level, serum triglyceride level, serum LDL level, serum HDL level with that of stroke severity on admission. Material& Methods: A randomized cross sectional study consisting of 150 stroke patients admitted in the department of Medicine, R.G.Kar. Medical College and Hospital, Kolkata from the period of 01.07.2014 to 31.06.2015 was done. Assessment of stroke severity was done by Scandinavian Stroke Scale. Serum fasting triglyceride, Serum fasting total cholesterol, Serum fasting LDL-C, Serum fasting HDL-C level measured between 12 and 36 hours after stroke onset. Result: Out of 150 cases, 82.67% cases were found to be due to ischemic stroke and rest 17.33% due to intracerebral stroke. There is statistically significant positive correlation between serum Total Cholesterol Vs SSS Score, and serum LDL-Cholesterol Vs SSS Score and serum Triglyceride vs SSS Score in Ischemic Stroke patients respectively (0.432, 0.319, 0.809 ) & also in intracranial Hemorrhage patients respectively (0.887,0.839,0.867).Correlation between serum HDL-Cholesterol and SSS Score in Ischemic Stroke and Intracranial Hemorrhage patients were not statistically significant (p > 0.05). Conclusion: Higher serum LDL-Cholesterol, Triglyceride and Total Cholesterol levels were independently associated with less severe stroke both in Ischemic Stroke (IS) and Intracerebral hemorrhage(ICH) cases.
