The study was to assess the Prescribing pattern, sensitivity Pattern and to compare the effectiveness of empirical versus evidence based antibiotic therapy in the infected patients. The subject with infection, their laboratory and culture report was to assess the incidence of antimicrobial resistance and sensitivity pattern. Prescription pattern of antibiotics, Sensitivity and resistance pattern of pathogen was analyzed by percentage. Blood parameters of each group was compared by student t test. A total of 107 prescriptions were analyzed. From this 69 patients (64.48%) were treated with empiric therapy and 38 patients (35.51%) were treated with definitive therapy. Out of 199 antibiotics Penicillin (26.63%), Fluoroquinolones (25.12%) and Cephalosporins (21.6%) were mostly prescribed. Most sensitive and resistant drugs were identified in isolated organisms. Comparison between empirical versus evidence based therapy was carried out by analyzing laboratory values. Judgmental use of antibiotic's reduce the burden of multidrug resistance and thereby enabling better patient management and limiting the resultant morbidity and mortality. Proper guidelines, supervision of antibiotic usage and constant information to the medical practitioners regarding the sensitivity pattern can helps to prevent drug resistance. Proper selection of therapy will improve quality of life
