Studying whether HCV infection is associated with osteoporosis or not , has yielded controversial results, especially so in Hemodialysis patients with superadded HCV infection . Forty patients on prevalent HD were included in this study. Twenty patients were HCV +ve and twenty patients were HCV – ve. For all patients, the following was done: Complete physical examination and DEXA T - & Z- scores of both lumbar and femoral regions, Hb, blood urea, serum creatinine, serum Iron, ALT, AST, CRP, serum Albumin, serum calcium, serum phosphorus, PTH, and serum Alkaline Phosphatase. We found that osteoporotic DEXA scores were more present among HCV + ve than HCV – ve patients (P < 0.05), and that lumbar region was more affected than femoral region in both groups.