Aim: The objective of this study was to correlate laboratory tests during the evolution of dengue Fever in order to use test results to predict the severity of the disease. Methods: This is an observational, descriptive and retrospective study of 60 patients with clinical, hematological, biochemical and serological diagnosis of dengue fever who, in the period from August to October 2015 were admitted in a pronounced hospital in lucknow. The tests analyzed were blood count, platelets, serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations along with card tests. Results: Leucopenia, thrombocytopenia, elevated transaminases and positive card test were observed in patients with dengue fever. Most laboratory abnormalities were already present on day of admission. Conclusion: These results are relevant in assessing the disease and follow up of the treatment started, because they can be used as markers for more severe forms andcan help by enabling the ada ptation of the therapeutic conduct to the needs of individual patients.