High disease prevalence rates continue to significantly impact illness and mortality rates of American children. Therefore, an investigation of specific identifiable risk factors which may be associated with negative health outcomes among children’s groups may therefore be warranted. A large randomly drawn sample (N = 422,599) of boys (n = 198.960) and girls (n = 223,639) ages 4 to 12, was examined in this research study to test for the association between disease prevalence and the factors of Healthcare Quality, Household Income, Race, and Gender. The Pearson Chi Square test for Association was applied to measure for significant variable associations in this research study. This research study examined inpatient admissions for pediatric patients using the Kids´ Inpatient Database (KID), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality (AHRQ, 2016). The results of this study found that there were statistically significant associations between negative disease outcomes and identifiable risk factors which were investigated (p< .05). The findings from this research study provide support for establishing the initiatives which may assist in reducing disease and illness rates among children’s groups.