Synthesis, Characterization, And Biological Activities Of Some New Five And Six Membered Heterocyclic Rings Derived From Chalcones By Fusion Method

Some novel heterocyclic derivatives such as dihydropyrimidine, dihydropyrimidine –thione, Isoxazoline, Pyrazoline, (II,III,IV,V) were synthesized from chalcone. Chalcone (I) were prepared by direct fusion method Claisen-schmidt condensation of suitable brominated acetophenones with suitable brominated benzaldehyde in the presence of sodium hydroxide up to fusion point. The newly synthesized compounds were characterized viaTLC, melting points, FT-IR, H1 -NMR, C13- NMR spectral data. All the compounds were tested for their antibacterial and antifungal activities by the cylinder-plate method