A copper (II) complex, (Cu (phen)(L-phe)(Ethylamine))(ClO4) (phen=1, 10- Phenanthroline, L-Phenylalanine), has been synthesized and characterized by IR, UV-Vis , EPR spectra and elemental analysis. Binding of this copper (II) complex with calf thymus DNA (CT-DNA) was investigated by UV–Visible absorption, fluorescence spectroscopic, cyclic voltametric and viscosity techniques. Also the interaction of pBR322 DNA with the same copper (II) complex was studied using the gel electrophoresis method. The complex was shown to bind DNA by different mode and cleave pBR322 DNA in the presence and absence of ascorbate. The copper (II) complex was tested for its antibacterial and antifungal activity and it was found to have good antibacterial and antifungal activities
