Objective: One Health acknowledges that the health of humans, animals, and the environment are interlinked. Ayurveda emphasizes a harmonious relationship with the environment, promoting the well-being of animals, plants, and humans. Ayurveda provides better solutions for holistic health by including proper dietary management and modification, lifestyle advice, Panchakarma procedures, medications, and Rasayan. In the last ten years, Ayurveda has demonstrated its effectiveness in treating common lifestyle diseases. Ayurveda offers various regimens, including Dinacharya, Panchakarma, and Rasayana therapies, as prophylactics for lifestyle diseases. These Ayurveda regimens can be applied on a broader scale throughout the nation. The Sadvrutta (ideal routine) and Aachara Rasayana are important in maintaining healthy socio-physiological well-being. This article recognizes the interdependence of humans and animals on each other, environmental health offering preventive measures, herbal remedies, and environmental stewardship that support the interconnected perspective. As the world faces increasing health challenges, embracing Ayurveda’s ancient wisdom can contribute to a more harmonious and sustainable approach to health, promoting the well-being of all living beings on our planet.