The occurrence of new cases of malignant tumors of the upper airways and digestive passages diagnosed in the world per year are about 870,000. In contrast to higher incidence rates of these malignancies in a developing countries, only neck cancer rates are been found to be highest and the choice treatment for these malignancies is surgery, associated or not with radiotherapy. Surgery and radiotherapy are the treatment options for the localized or regional disease. Since radiotherapyinduced oral complications cause high morbidity and a decrease in quality of life, the aim of this review is to acknowledge the main mutilating oral effects caused by oral cancer therapies and a special attention to be given to the post therapies adverse effects before initialization of any treatment.
