Background: Vitamin D is a pro-hormone that not only regulates blood calcium levels, but has many other beneficial actions.
Objective: We aim to estimate serum 25(OH) Vitamin D and i-PTH (intactparathyroid hormone) levels in hypothyroidism.
Methods: 100 subjects were included in the study and patients having serum hTSH > 10 μIU/L or serum hTSH levels between 6 to 10 μIU/L along with decreased serum FT3 &/or FT4 levels were diagnosed as hypothyroid cases. Serum 25(OH) Vitamin D was estimated using ELISA. Serum hTSH & serum i-PTH assay was based on chemiluminescence. Statistical analysis was done (SPSS).
Results: We observed that 25(OH) Vitamin D levels were significantly lower in hypothyroid patients (20.0 ± 1.49 ng/ml) compared to controls (27.7 ± 1.34 ng/ml), p < 0.001. A negative and significant correlation was observed between 25(OH) Vitamin D and hTSH levels (r= -0.48, p < 0.001). i-PTH levels were significantly increased in hypothyroid patients (57.6 ± 3.30 pg/ml) vs (36.8 ± 1.91 pg/ml), though a significant correlation was not observed between i-PTH & hTSH among cases (r=0.11, p= 0.43).
Conclusions: Hypothyroid patients frequently bespeak a Vitamin D deficient state which suggests that they need routine screening and supplementation for the same.
