Design and synthesis of newer schiff base derivatives integrating sydnones and benzo[d]thiazole as potential antimicrobial agents
Sydnones are very important members of the class mesoionic compounds. A series of schiff base derivatives has been synthesized by condensing 4-(((4-aminophenyl) amino) methyl)-3-(3-nitrophenyl)sydnone with KCNS and Br2 in presence of glacial HAc- followed by the reaction with substituted aromatic aldehydes. The synthesized compounds were characterised and evaluated for antimicrobial activities. The newly synthesized compounds were screened against representatives of Gram-positive and Gram-negative bacteria and fungi.