The present study deals with anthelmintic activity of bark of Dalbergia sissoo (Fabaacae), a potential medicinal plant, distributed in open forests in India. The plant is used in traditional medicine for Dyspepsia and Dysentery. Expectorant, Aphrodisiac, Abortifacient, Anthelmintic, Antipyretic and Diseases of the blood, Leucoderma, The petroleum ether, ethyl acetate, methanol and ethanol were evaluated for its anthelmintic activity against adult Indian earthworms (Pheretima posthuma). Three concentrations (25, 50 and 75mg/ml) of each extract were studied, which involved for the determination of time of paralysis and time of death of the test worms. It was found that ethanol and Petroleum ether extracts exhibited significant anthelmintic activity. Albendazole in same concentration as that of extract was used as standard reference and saline water as control.