Background: Gastroesophageal reflux disease (GERD) has become a major health problem globally. It is a chronic, painful disease which has substantial effects on the everyday lives of affected individuals. GERD often needs long-term treatment and it can affect quality of life by disturbing the quality of eating and drinking, physical activities and rest. Therefore, improved quality of life has become another target of GERD management. The reflux symptom questionnaire 7 day recall (RESQ 7) are PRO (patient related outcome) instruments that were developed and validated for measuring the intensity and frequency of GERD symptoms in patients with a partial response to PPI’s. AIM: To assessthe Patients Health Related Quality of Life Associated with GERD in our Indian community Methods: By using randomized open label cohort study,150 GERD Patients between 20-80 Years Males and females, out patients were assessed to health related quality of life. GERD Patients were invited to complete the GERD Questionnaire (RESQ 7) and the results were evaluated by using the likert scale. Results: A Total of 150 patients diagnosed with GERD, in that 117(78.10%) were Males and 33 (21.09%) were Females. In 150 Cases, 115 Patients ( 76.82%) were diagnosed as grade A GERD, 27 patients (17.88%) were grade B, 6 Patients (3.97%) were grade C and 2 Patients(1.32%) were diagnosed as grade D GERD. Conclusion: Our study reveals 118 are adhere to the given therapy, with improved outcomes out of 150 patients. Patients, who have with improved outcomes, overcame sleeping problems (90), and professional difficulties (81). Our study assessed males (117) are more susceptible for GERD than females (33). And 36- 45 year age group patients are more. We noticed that Endoscopic GRADE -A patients (115) are more.